新型单羰基姜黄素类似物的合成及抗肿瘤活性研究

采用氮烷基化、羟基保护、醛酮缩合三步反应合成了8个新型单羰基姜黄素类似物,结构经质谱、核磁共振氢谱和核磁共振碳谱等手段进行确认。并采用MTT染色法体外检测所合成的8个单羰基姜黄素类似物对人肺癌细胞H1299,结肠癌细胞HT-29,人体胰腺癌细胞BxPC-3和人前列腺癌细胞PC-3的抗癌活性。半数抑制浓度IC50值结果显示:所合成的8个姜黄素类似物对四种细胞均有较强的抑制作用,其中化合物A6在四种细胞中的半数抑制浓度IC50均在0.65 μM以下,抗癌活性比姜黄素提高了40倍以上。     

基于DSP+CPLD的大功率高效电动汽车充电电源

多单机充电模块并联运行方式在充电后期或是在给电池容量较小的电动汽车充电时,各充电模块均处于轻载状态,且充电电源效率低下,谐波污染严重.为此,文中研制了一款基于DSP+CPLD的ZVZCS大功率电动汽车充电电源模块,搭建了输出功率可达288 kW(600 V/480 A)的实验平台,并提出了一种新型的并联控制策略,该控制策略确保始终以最少的充电模块提供电动汽车所需的充电电流(电压).实验结果表明:单机运行时,充电电源的效率在满载时最高可达96.5%;多单机并联运行时,运用上述控制策略可使充电电源效率始终保持在90.0%以上.     

基于跳-扩散过程的振动系统的模态识别方法(英文)

本文提出了Lévy激励下LTI系统的一种时域模态识别方法.系统响应可看做是一个跳-扩散过程.基于二次变差和多幂次变差的性质,跳-扩散过程被分解成扩散过程和纯跳激励的过程,二者都具有和原系统相同的未知参数.最后通过扩散过程的极大似然估计方法来估计Lévy激励下LTI系统的参数.数值结果表明该方法估计精度高.     

Effect of ytterbium on sodium current and its kinetics in rat hippocampal neurons

This study addressed the effects of Yb3＋ on voltage-gated sodium currents in rat hippocampal neurons using the whole-cell patch-clamp technique. Voltage-clamp recordings in single neurons were filtered and stored in a computer. Yb3＋ increased the amplitude of sodium currents in a concentration-dependent and voltage-dependent man- ner. The 50 % enhancement concentration of Yb3＋ on sodium currents was about 8.97 μmol/L, which was dif- ferent from the inhibitory effects of Yb3＋ on potassium current. The analysis on the activation and inactivation kinetics of Na＋ current showed that 100 μmol/L Yb3＋ did not change the process of activation and inactivation. In addition, the times reaching the peak of current （t） and inactivated time constant （τ） were voltage dependent. 100 μmol/L Yb3＋ significantly prolonged the time to peak at -70 and -80 mV. The effect disappeared at the positive direction of -70 mV. Furthermore, Yb3＋ decreased r val- ues to more positive values than -80 mV. In total, Yb3＋ did not change the process of activation, but impelled inacti- vated process. Yb3＋ mainly increased the Na＋ current through changing its conductance. It might be one of the mechanisms that Yb3＋ affected the hippocampal neurons.     

Progress of transition metal-catalyzed cross-coupling mediated by PyBroP

In the transition metal-catalyzed cross-coupling reactions, phenol and enol derivatives activated by phos- phorus groups are very important electrophiles. This kind of compounds has the advantages of easy preparation, great stability, and producing more benign phosphorus by-pro- ducts. The present work provides a comprehensive review of the advances made over the past several decades in this area. Cross-coupling reactions mediated by PyBroP are first surveyed, then two types of recently developed tran- sition metal-catalyzed reactions, i.e., Pd-catalyzed and Ni- catalyzed reactions, and the corresponding mechanisms are discussed. Finally, future directions are analyzed.     

双氧水氧化废轮胎胶粉在改性沥青中的应用

采用双氧水对废轮胎胶粉进行表面氧化改性,将氧化改性胶粉用于制备胶粉改性沥青.通过XPS表征证明氧化改性胶粉表面的C—O和C=O的含量显著增加.通过多因素正交试验方法研究氧化剂用量、氧化温度及氧化时间对胶粉改性沥青的25,℃针入度、软化点和5,℃延度等主要性能指标的影响.运用极差分析法和方差分析法探讨了各影响因素对改性沥青性能的敏感性,发现氧化温度对改性沥青性能指标的影响最大,并提出了胶粉氧化改性的最佳反应条件为:氧化剂用量10,m L,氧化温度80,℃,氧化时间3,h.氧化胶粉改性沥青在不使用界面改性剂的条件下,能够使5,℃延度提高到11.6,cm,主要性能指标达到美国废轮胎胶粉改性沥青标准,说明废轮胎胶粉的表面氧化能够显著提高胶粉与沥青的界面结合强度.     

新型聚合物聚乙二醇-胆酸(PEG-CA)自组装为胶束负载药物的研究

设计并合成了一种具有特定结构的新型聚合物:聚乙二醇-胆酸(PEG-CA),并分别采用核磁共振、红外光谱等表征手段确定聚合物的结构,然后通过Zeta-Plus电位粒径仪测得其自组装后胶束的粒径大小及分布。最后测定了聚乙二醇-胆酸(PEG-CA)胶束负载阿霉素(DOX)的载药量。实验结果表明聚合物聚乙二醇-胆酸(PEG-CA)具有作为纳米药物载体的药物输送的潜在应用。     

西藏拉萨地区198株结核分枝杆菌耐药性分析

目的：了解拉萨地区结核分枝杆菌对抗结核药物的耐药情况,为临床合理用药提供参考依据。方法：采用WHO推荐的比例法对分离自西藏拉萨地区肺结核患者的198株结核分枝杆菌进行4种抗结核药物（RFP、INH、SM、LVX）的药物敏感性试验。结果：198株结核分枝杆菌中耐药菌株有125株,总耐药率为63.1%（125/198）,总耐多药率为29.8%（59/198）,初治耐药率为55.1%（64/116）,复治耐药率为75.4%（40/53）,初治耐多药率为20.7%（24/116）,复治耐多药率为56.7%（30/53）。对RFP、INH、SM、LVX的耐药率分别为36.3%（72/198）、41.9%（83/198）、41.4%（82/198）和7.0%（14/198）。结论：西藏拉萨地区临床结核分枝杆菌耐药情况较为严重,应加强临床结核分枝杆菌耐药性监测,指导临床用药以防控耐药菌的产生。     

基于APDL的全地面起重机臂架分析

大吨位全地面起重机由于其吊载大、结构复杂,对臂架的结构强度稳定性有很高的要求,因此对臂架结构的计算成为设计的关键。一般的有限元计算方法将主臂简化为beam单元进行分析,这种方法计算简单,建模效率高,但只能对臂架整体应力分布进行分析。采用shell单元对主臂进行建模分析,分析精确,但建模复杂,分析效率低。利用APDL开发基于MATLAB的臂架各工况批量分析程序,可针对不同工况的臂架进行建模组装,提高了计算的效率。     

A trusted mobile payment environment based on trusted computing and virtualization technology

In this paper, we propose a trusted mobile payment environment （TMPE） based on trusted computing and virtualization technology. There are a normal operating system （OS） and a trusted OS （TOS） in TMPE. We store the image of TOS in a memory card to hinder tampering. The integrity of TOS is protected by means of a trusted platform module （TPM）. TOS can only be updated through a trusted third party. In addition, virtualization technology is applied to isolate TOS from normal OS. Users complete ordinary affairs in normal OS and security-sensitive affairs in TOS. TMPE can offer users a highly protected environment for mobile payment. Moreover, TMPE has good compatibility in different hardware architectures of mobile platforms. As the evaluation shows, TMPE satisfies the requirement of mobile payment well.